Principle & Method

This method is based principle is based on the temporarily opening of pores on the Red Cells’ membrane, through which the products to be encapsulated (conventional drugs, peptides, proteins, nucleic acids, dyes, nanoparticles, etc.) can be carried. The opening of pores happens when erythrocytes are placed in hypotonic (salt concentration lower than physiologic condition) environment.

These pores are then sealed again once normal osmosis is restored and the drug excess which is not encapsulated, is washed away. Once administered back to the donor, these erythrocytes circulate normally, maintain their property of oxygen transporters, maintain a normal morphology and normal biochemical and rheological features.

US patent 6,139,836 | EU patent 882448 | Japan patent 123228

This procedure is currently achieved thanks to a medical equipment called “Red Cell Loader” and a dedicated CE Marked disposable kit.

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