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Credentials and contents in the EryDel “RESERVED AREA” are strictly confidential and the access is authorized only for the medical staff operating the EDS in the ATTeST study. The Content of the “RESERVED AREA” should not be copied, distributed or reproduced in whole or in part, nor distributed to any third party if not for the  training purpose of authorized EDS Operators. The Content of the “RESERVED AREA” is only for medically trained staff.

I Agree

  1. Pascucci T., Rossi L., Colamartino M., Gabucci C., Carducci C., Valzania A., Sasso V., Bigini N., Pierigè F., Viscomi M.T., Ventura R., Cabib S., Magnani M., Puglisi-Allegra S., Leuzzi V. A new therapy prevents intellectual disability in mouse with phenylketonuria. Mol. Genet. Metab. 2018; 124:39-49.
  2. Mambrini G., Mandolini M., Rossi L., Pierigè F., Capogrossi G., Salvati P., Serafini S., Benatti L., Magnani M. Ex vivo encapsulation of dexamethasone sodium phosphate into human autologous erythrocytes using fully automated biomedical equipment. Int J Pharm. 2017 Jan 30; 517(1-2):175-184. doi: 0.1016/j.ijpharm.2016.12.011.
  3. Pierigè F., Bigini N., Rossi L., Magnani M. Reengineering red blood cells for cellular therapeutics and diagnostics. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jan 24. doi: 10.1002/wnan.1454. [Epub ahead of print] Review.
  4. Menotta M., Biagiotti S., Bartolini G., Marzia B., Orazi S., Germani A., Chessa L., Magnani M. Nano-Mechanical Characterization of Ataxia Telangiectasia Cells Treated with Dexamethasone. Cell Biochem Biophys. 2016 Dec 8. [Epub ahead of print]
  5. Rossi L., Pierigè F., Antonelli A., Bigini N., Gabucci C., Peiretti E., Magnani M. Engineering erythrocytes for the modulation of drugs' and contrasting agents' pharmacokinetics and biodistribution. Adv Drug Deliv Rev. 2016 Nov 15; 106(Pt A):73-87. doi: 10.1016/j.addr.2016.05.008. Review.
  6. Biagiotti S., Menotta M., Orazi S., Spapperi C., Brundu S., Fraternale A., Bianchi M., Rossi L., Chessa L., Magnani M. Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response. FEBS J. 2016 Nov; 283(21):3962-3978. doi: 10.1111/febs.13901.
  7. Antonelli A., Sfara C., Weber O., Pison U., Manuali E., Salamida S., Magnani M. Characterization of ferucarbotran-loaded RBCs as long circulating magnetic contrast agents. Nanomedicine (Lond). 2016 Oct 14. [Epub ahead of print]
  8. Leuzzi V., Rossi L., Gabucci C., Nardecchia F., Magnani M. Erythrocyte-mediated delivery of recombinant enzymes. J Inherit Metab Dis. 2016 Jul; 39(4):519-30. doi: 10.1007/s10545-016-9926-0.
  9. Leuzzi V., Micheli R., D'Agnano D., Molinaro A., Venturi T., Plebani A.Soresina A., Marini M., Ferremi P., Quinti I., Pietrogrande M., Finocchi A., Fazzi E., Chessa L., Magnani M. Positive effect of erytrocyte-delivered dexamathasone in ataxia-telangiectasia. Neurol Neuroimmunol Neuroinflamm 2015;2: e98.
  10. Magnani M., Rossi L. Approaches to erythrocytes-mediated drug delivery 10.1517/17425247.2014.889679 2014 Informa UK, Ltd ISSN 1742-5247, e-ISSN 1744-7593
  11. Sabatino R., Antonelli A., Battistelli S., Schwendener R., Magnani M., Rossi L. Macrophage depletion by free bisphosphonates and zoledronate-loaded red blood. PloS One 2014 Jun 26; 9(6):e101260.doi:10.1371/journal.pone.0101260.eCollection 2014.
  12. Rossi L., Pierigè F., Carducci C., Pascucci T., Canonico B., Bell SM., Fitzpatrick PA., Leuzzi V., Magnani M. Erytrocyte-mediated delivery of phenylalanine ammonia lyase for the treatment of phenylketonuria in BTBR-Pah(enu2) mice. J. Control Release 2014 Nov 28; 194:37-44. doi 10.1016/j.jconrel.2014.08.012 Epub 2014 Aug 23
  13. Chessa L., Leuzzi V., Plebani A., Soresina A., Micheli R., D’Agnano D., Venturi T., Molinaro A., Fazzi E., Marini M., Ferremi Leali P., Quinti I., Cavaliere F.M., Girelli G., Pietrogrande M.C., Finocchi A., Taboli S., Abeni D., Magnani M. Intra-erythrocyte infusion of dexamethasone reduces neurlogical symptoms in ataxia teleangiectasia patients: results of a phase 2 trial. Orphanet J. Rare Dis. Jan 9; 9(1):5, 2014
  14. Bossa F., Annese V., Valavano M.R., Latiano A., Martino G., Rossi L., Magnani M., Palmieri O., Serafini S., Damonte G., De Santo E., Andriulli A. Erythrocyte-mediated delivery of Dexamethasone 21-phosphate in Steroid-dependent Ulcerative Colitis: A Randomized, Double-blind Sham-controlled Study. Inflamm. Bowel Dis. 2013; 19: 1872-1879
  15. Antonelli A., Sfara C., Magnani M., Ralmer J., Gleich B., Borgert J., Weizenecker J. Red Blood Cells as magnetic carriers for MPI application. In: T.M. Bozung and J. Borgert eds. Magnetic Particle Imaging, Spriger Proc. Phys. 2012: 140: 175-179
  16. Menotta M., Biagiotti S., Bianchi M., Chessa L., Magnani M. Dexamethasone partially rescues Ataxia Teleangiectasia-Mutated (ATM) deficiency in Ataxia-Telangiectasia by promoting a shortened protein variant retaining kinase activity. J. Biol. Chem. 2012: 287; 41352-41363
  17. Magnani M., Pierigè F., Rossi L. Erythrocytes as a novel delivery vehicle for biologics: from enzymes to nucleic acid-based therapeutics. Ther. Deliv. 2012: 3(3): 405-414
  18. Magnani M. Erythrocytes as carriers for drugs: the transition from the laboratory to the clinic is approaching. Expert Opin. Biol. Ther. 2011: 12(2): 137-138
  19. Biagiotti S., Rossi L., Bianchi M., Giacomini E., Pierigè F., Serafini S., Conaldi P.G., Magnani M. Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs. J. Control Release 2011: 154(3): 306-313
  20. Antonelli A., Sfara C., Manuali E., Bruce I.J., Magnani M. Encapsulation of superparamagnetic nanoparticles into red blood cells as new carrier of MRI contrast agents. Nanomedicine (Lond.) 2011: 6(2): 211-223
  21. Biagiotti S., Paoletti M.F., Fraternale A., Rossi L., Magnani M. Drug delivery by red blood cells. IUBMB Life 2011: 63(8): 621-631
  22. Magnani M., Serafini S., Fraternale A., Antonelli A., Biagiotti S., Pierigè F., Sfara C., Rossi L. Red Blood Cell-based delivery for drugs and nanomaterials for therapeutic and diagnostic applications . Encyclopedia of Nanoscience and Nanotechnology Ed. H.S. Nalwa 2010: Vol. X: 1-46
  23. Markov D.E., Boeve H., Gleich B., Borgert J., Antonelli A., Sfara C., Magnani M. SPIO Nanoparticles encapsualtion into Human Erythrocytes for MPI Application. In: T.M. Bozung, J. Borgert eds., Magnetic Nanoparticles . Particle Science, Imagin Technology and Clinical Applications World Scientific 2010: 26-31
  24. Markov D.E., Boeve H., Gleich B., Borgert J., Antonelli A., Sfara C., Magnani M. Human erythrocytes as nanoparticle carriers for magnetic particle imaging. Phys. Med. Biol. 2010: 55 (21): 6461-6473
  25. Pierigè F., De Marco C., Orlotti N., Dominici S., Biagiotti S., Serafini S., Zaffaroni N., Magnani M. Cytotoxic activity of 2-Fluoro-ara-AMP and 2-Fluoro-ara-AMP loaded erythrocytes against human breast carcinoma cell lines. Int. J. Oncol. 2010: 37(1): 133-142
  26. Fraternale A., Paoletti M.F., Casabianca A., Orlandi C., Millo E., Balestra E., Damonte G., Perno C.F., Magnani M. Erythrocytes as carriers of antisense PNA addressed against HIV-1-gag-pol trans fame domain. J. Drug Target. 2009: 17(4): 278-285
  27. Pierigè F., Serafini S., Rossi L., Magnani M. Cell-based drug delivery. Adv. Drug Deliv. Rev. 2008: 60: 286-295
  28. Flower R., Peiretti E., Magnani M., Rossi L., Serafini S., Gryczynski Z., Gryczynski I. Observation of Erythrocyte dynamics in the Retinal Capillaries and Choriocapillaries Using IGC-loaded Erythrocyte Ghost Cells. Invest Ophtalmol. Vis. Sci. 2008: 49: 1-7
  29. Bossa F., Latiano A., Rossi L., Magnani M., Palmieri O., Dallapiccola B., Serafini S., Damonte G., De Santo E., Andriulli A., Annese V. Erythrocyte-mediated delivery of Dexamethasone in patients with mild-to-moderate Ulcerative Colitis, refractory to Mesalamine: A Randomized Controlled Study . Am. J. Gastroenterol. 2008: 103: 1-8
  30. Castro M., Rossi L., Papadatou B., Bracci F., Knafelz D., Ambrosini M.I., Calce A., Serafini S., Isacchi G., D'Orio F., Mambrini G., Magnani M. Long term treatment with autologous red blood cells loaded with dexamethasone 21-phosphate in pediatric patients affected by steroid-dependent Crohn's disease. J. Ped. Gastroenterol. Nutr. 2007: 44: 423-426
  31. Rossi L., Serafini S., Pierigè F., Castro M., Ambrosini M.I., Knafelz D., Damonte G., Annese V., Latiano A., Bossa F., Magnani M. Erythrocytes as a controlled drug delivery system: clinical evidences. J. Control Release 2006: 116: 43-45
  32. Castro M., Knafelz D., Rossi L., Ambrosini M.I., Papadatou B., Mambrini G., Magnani M. Periodic treatment with autologous erythrocytes loaded with dexamethasone 21-phosphate for fistulizing pediatric Crohn's disease: case report. J. Ped. Gastroenterol. Nutr. 2006: 42: 313-315
  33. Annese V., Latiano A., Rossi L., Bossa F., Damonte G., Dallapiccola B., Serafini S., Pierigè F., Andriulli A., Magnani M. The polymorphism of multi-drug resistance 1 gene (MDR 1) does not influence the pharmacokinetics of dexamethasone loaded into autologous erythrocytes of patients with inflammatory bowel disease. Eur. Rev. Med. Pharmacol. Sci. 2006: 10: 27-31
  34. Magnani M., Paiardini M., Cervasi B., Serafini S., FraternaleA., Silvestri G. Fludarabine delivery by autologous Red Blood Cells induces macrophage depletion in chemically SIV-infected Sooty Mangabeys 2006: 116(2): 45-47
  35. Lucidi V., Tozzi A.E., Bella S., Turchetta A. A pilot trial on safety and efficacy of erythrocyte-mediated steroid treatment in CF patients . BMC Pediatrics 2006: 6: 17
  36. Latiano A., Bossa F., Magnani M. Erythrocytes as a controller drug delivery system: clinical evidences. J. Control Release 2006: 116(2): 43-45
  37. Cervasi P., Paiardini M., Serafini S., Fraternale A., Menotta M., Engram J., Lawson B., Staprans S.I., Piedimonte G., Perno C.F., Silvestri G., Magnani M. Administration of Fludarabine-loaded autologous Red Blood Cells in Simian Immunodeficiency Virus-Infected Sooty Mangabeys depletes pSTAT-1 expressing Macrophages and delays the rebound of viremia after suspension of Antiretroviral Therapy. J. of Virology 2006: 80,21: 10335-10345
  38. Annese V., Latiano A., Rossi L., Lombardi G., Dallapiccola B., Serafini S., Damonte G. , Andriulli A., Magnani M. Erythrocytes-mediated delivery of dexamethasone in steroid-dependent IBD patients- a pilot uncontrolled study. Am.J. Gastroenterol. 2005: 100: 1370-1375
  39. Rossi L., Serafini S., Antonelli A., Pierigè F., Carnevali A., Battistelli V., Malatesta M., Balestra E., Calio R., Perno C.F., Silvestri G., Magnani M. Macrophage depletion induced by clodronate-loaded erythrocytes. J. Drug Target. 2005: 13(2): 99-111
  40. Rossi L., Serafini S., Pierigè F., Antonelli A., Cerasi A., Fraternale A., Chiarantini L., Magnani M. Erythrocytes-based drug delivery. Expert Opin. Drug Deliv. 2005: 2(2): 311-322
  41. Rossi L., Castro M., D'Orio F., Damonte G., Serafini S., Bigi L., Panzani I., Novelli G., Dallapiccola B., Panunzi S., Di Carlo P., Bella S., Magnani M. Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patients. Blood Cells Mol. Dis. 2004: 33: 57-63
  42. Magnani M. Erythrocytes Engeneering for drug delivery and targeting. Kluver Academic/Plenum Publishers 2003: 1-146
  43. Fraternale A., Casabianca A., Rossi L., Chiarantini L., Schiavano G.F., Palamara A.T., Garaci E., Magnani M. Erythrocytes as carriers of reduced glutathione (GSH) in the treatment of retroviral infections . J. Antimicrob. Chemother. 2003: 52(4): 551-554
  44. Magnani M., Rossi L, Fraternale A., Aquaro S., Paiardini M., Cervasi B., Casabianca A., Garaci E., Perno C.F. Drug-loaded red blood cell-mediated clearance of HIV-1 macrophage reservoir by selective inhibition of STAT 1 expression. J. Leukoc. Biol. 2003 : 74(5): 764-771
  45. Magnani M., Rossi L, Fraternale A., Bianchi M., Antonelli A., Crinelli R., Chiarantini L. Erythrocyte-mediated delivery of drugs: peptides and modified oligonucleotidis . Gene Ther. 2002: 9(11): 749-751
  46. Fraternale A., Casabianca A., Orlandi C., Cerasi A., Chiarantini L., Brandi G., Magnani M. Macrophage depletion by addition of glutathion (GSH)-loaded erythrocytes to AZT and DDI in a murine AIDS model. Antiviral Res. 2002: 56(3): 263-272
  47. Rossi L., Serafini S., Cenerini L., Picardi F., Bigi L., Panzani I., Magnani M. Erythrocyte-mediated delivery of dexamethasone in patients with chronic obstructive pulmonary disease. Biotechnol. Appl. Biochem. 2001: 33: 85-89
  48. Rossi L., Serafini S., Cappellacci L., Balestra E., Brandi G., Schiavano G.F., Franchetti P., Grifantini M., Perno C.F., Magnani M. Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus. J. Antimicrob. Chemother. 2001: 47(6) : 819-827
  49. Franchetti P., Rossi L., Cappellacci L., Pasqualini M., Grifantini M., Balestra E., Forbici F., Perno C.F., Serafini S., Magnani M. Inhibition of HIV-1 replication in macrophages by red blood cells-mediated delivery of a heterodinucleotide of azidothymidine and 9-(R )- 2 – (phosphono methoxypropyl) adenine. Antivir. Chem. Chemother. 2001: 12(3): 151-159
  50. Crinelli R., Antonelli A., Chiarantini L., Mancini U., Magnani M. Selective inhibition of NK-kB activation and TNF-α production in macrophages by red blood cell-mediated delivery of dexamethasone. Blood Cells Mol. Dis. 2000: 26(3): 211-222
  51. Magnani M., Rossi L., D'Ascenzo M, Panzani I., Bigi L. Zanella A. Erythrocyte engineering for drug delivery and targeting. Biotechnol. Appl. Biochem. 1998: 28 (pt1): 1-6
  52. D'Ascenzo M., Antonelli A., Chiarantini L., Mancini U., Magnani M. Red Blood Cells as a glucocorticoids delivery system. In: Erythrocytes as drug carriers in medicine, Sprandel U., Way J.L., Ed. Plenum Press New York 1997: 81-88

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